There have been several famous people with the surname Waterhouse:

• Alfred Waterhouse (1830 - 1905), English architect.
• George Robert Waterhouse (1810 - 1888), English naturalist.
• John Waterhouse, Halifax photographer, and inventor in 1858 of diaphragms known as Waterhouse stops.
• John William Waterhouse (1849 - 1917), British Pre-Raphaelite painter.
• Keith Waterhouse (born 1929), English writer.
• Matthew Waterhouse, the actor who played Adric in the television series Doctor Who.