Guthrie may refer to the following places:
and to the following people
- Arlo Guthrie, folk singer;
- Woody Guthrie, folk singer (and father of Arlo Guthrie);
- Malcolm Guthrie, professor of Bantu languages
- Francis Guthrie, a mathematician famous for first stating the four color problem;
- Samuel Guthrie (1782-1848), physician, discoverer of chloroform;
- Thomas Guthrie, a 19th century philanthropist;
- Sir Tyrone Guthrie, English stage director, playwright, founder of Guthrie Theater
- Frederick Guthrie, British scientific writer and professor;
- Hugh Guthrie, a Canadian politician and Cabinet minister
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